ABSTRACT

Palmar-plantar erthrodyesthesıa (PPE) (hand and foot syndrome) is a dermatological toxic reaction related to some chematherapeutic agents. Liposomal doxorubicin is the long-acting formula of doxorubisin and it causes PPE in 50% of the patients when used with the dosage of 50 mg/m2. The disease causes burning sensation in the hands and feet and then shows progression by edema and erythema. After the disease is estbalished the treatment consists of lowering the drug dosage, prolonging the dose intervals or discontinuing the drug as well as using topical agents.