E-ISSN: 2149-9330
The value of colposcopy, high risk HPV-DNA and histopathologic examination in the management of abnormal Pap smear results
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Clinical Investigation
VOLUME: 8 ISSUE: 4
P: 272-278
December 2011

The value of colposcopy, high risk HPV-DNA and histopathologic examination in the management of abnormal Pap smear results

Turk J Obstet Gynecol 2011;8(4):272-278
DOI: 10.5505/tjod.2011.94914
Vugar Bayramov 1
Yavuz Emre Şükür 2
Sevgi Tezcan 2
1. Department Of Obstetrics And Gynecology, Merkezi Gumruk Hospital, Baki, Azerbaijan
2. Department Of Obstetrics And Gynecology, Ankara University, Ankara, Turkey
No information available.
No information available
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ABSTRACT

Objective:

Pap smear test is a major screening test for early diagnosis and treatment of cervix cancer. The aim of our study was to assess the value of HPV-DNA, colposcopy and histopathologic examination in the management of patients with abnormal cervical cytology.

Materials and methods:

This prospective cohort study was conducted in Ankara University Cebeci Hospital gynecology outpatient clinic. The study compremised 86 patients with smear results of ASCUS, AGC, L-SIL and H-SIL. Age, gravity, parity, age at first coitus, smoking status, number of partners, high risk HPV-DNA status and pathologic colposcopy findings were investigated.

Results:

Mean age of the patients was 35 years and the most common abnormal smear result was ASCUS, with 55 patients (63%). There was no significant difference between the groups regarding demographic characteristics except age at first coitus and pathologic colposcopy findings. Among patients diagnosed as ASCUS 34.5% had been up-graded with histopathologic examination. Among patients diagnosed as L-SIL 73.6% had been down-graded with histopathologic examination. However, after the histopathologic exam of 9 H-SIL patients two (22.2%) were diagnosed as CIN II, two (22.2%) were diagnosed as CIN III and one (11.1%) was diagnosed as cervical cancer. In the groups of ASCUS, L-SIL and H-SIL the presence of high risk HPV-DNA were 11%, 5% and 33%, respectively.

Conclusion:

If we are sure that the patient will attend the follow-up visits, then fort he ones with ASCUS and L-SIL a repeat smear test would be the appropriate. However, in the management of patients with H-SIL colposcopic biopsy would be the best approach.