ABSTRACT

OBJECTIVE:

To investigate the effects of endometrial thickness measurements and serum hormone levels on the outcomes of long protocol GnRH agonist ICSI cycles.

STUDY DESIGN:

Forty consecutive infertile women undergoing controlled ovarian hyperstimulation with recombinant FSH and GnRH agonists for ICSI were enrolled in this study. Age of the patients, day 3 FSH, antral follicle count (AFS), serum E2 levels on day 3, E2 on stimulation day 5, E2 on day of hCG administration, endometrial thickness on the baseline (EKbazal), on day 5 of stimulation (EK5), on day of hCG administration (EKhCG) and cycle outcomes were recorded. The outcomes of pregnant and non-pregnant women were compared.

RESULTS:

Women’s age was 27,4 ± 4,8. Overall pregnancy rate was %45 (n = 18) and spontaneous abortion rate was %11,1 (n = 2). In pregnant women, EK5, EKhCG, ∆EKhCG-Bazal values were significantly higher than non-pregnant women. There were no significant differences in estradiol and progesteron levels between pregnant and non-pregnant women.

CONCLUSION:

For achieving pregnancy, endometrial thickness may be a determining factor in GnRH agonist down-regulated ICSI cycles.