E-ISSN: 2149-9330
Sperm DNA damage and assisted reproductive techniques
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Review
VOLUME: 11 ISSUE: 1
P: 52-58
March 2014

Sperm DNA damage and assisted reproductive techniques

Turk J Obstet Gynecol 2014;11(1):52-58
DOI: 10.5505/tjod.2014.82584
Fazilet Kübra Boynukalın 1
Süleyman Güven 2
Serdar Günalp 3
1. Anatolia Ivf Center, Ankara
2. Karadeniz Technical University, School Of Medicine, Department Of Obstetrics And Gynecology, Trabzon
3. Hacettepe University, School Of Medicine, Department Of Obstetrics And Gynecology, Ankara
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ABSTRACT

Infertility affects one in six couples of childbearing age and male problems are responsible for 40% of these cases. One area of research that has been studied intensely during the past decade as a cause for male infertility is the integrity of DNA in the nucleus of mature ejaculated spermatozoa. Accumulating evidence suggests that disturbances in the organization of the genomic material in sperm nuclei are negatively correlated with the fertility potential of spermatozoa in vivo. The impact of sperm DNA damage on IVF and ICSI reproductive outcomes remain more controversial. Although no significant prognostic factor for the outcomes of assisted reproductive technique (ART) has been identified, except female age; there is accumulating evidence suggesting potential as a prognostic test for ART. The aim of this review to assess the evidence pertaining to the clinical utility of sperm DNA integrity testing and target areas that require more study.