ABSTRACT

Aim:

To evaluate epimediologic and prognostic factors of the patients with epithelial ovarian cancer retrospectively and to investigate the factors that effect overall survival.

Material and Method:

Between January 1990 and December 2004, 149 patients with malign epithelial ovarian tumor were included to this study. Age, parity, primary complaint and postoperative histopathology, surgical stage and maximal diameter of residual tumor of the patients were obtained and factors that effect overall survival were evaluated.

Results:

Mean age of the patients was 52.8 ± 13 years. Most of the patients were multipar (85.9%) and most fruquent (n: 88) (59.1%) complaint was abdominal swelling. Postoperative surgical stages were stage I in 24 (16.1%), stage II in11 (7.4%), stage III in 87 (58.4%) and stage IV in 27 (18.1%) patients. Maximal diameter of residual tumor was <1 cm in 68 patinets (45.6%), ≥1 cm in 57 patients (38.3%) while there was no residual tumor in 24 patients (16.1%). Histopathologic cell types distributed as: serous (53.6%), endometrioid (16.7%), musinous (10.7%), clear cell (10.7%), others (7.8%). The patinets <65 years old had similar overall survival compared to those who were ≥65 years old (p>0.05). The mean overall survival of the patients with maximal residual tumor size ≤1 cm, >1cm and no residual tumor were obtained to be 54.8 months, 22.7 months and 43.5 months respectively (p<0.001). According to the surgical stages I,II,III and IV mean survival was 78.5 months, 60.1 months, 33.9 months and 16.1 months respectively and significantly different (p<0.001).

Conclusion:

The data of the study revealed that surgical stage and postoperative maximum rezidual tumor diameter had significantly effect on overall survival where it was not effected by the age of the patients in epitelial ovarian cancers. So, early diagnosis and optimal cytoreduction should be attemped to improve the prognosis of the patients.