E-ISSN: 2149-9330
Placental apoptosis in preeclampsia
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Clinical Investigation
VOLUME: 10 ISSUE: 3
P: 125-131
September 2013

Placental apoptosis in preeclampsia

Turk J Obstet Gynecol 2013;10(3):125-131
DOI: 10.5505/tjod.2013.08769
Özgür Öktem 1
Esin Kotiloğlu 2
Tangül San 3
Zehra Neşe Kavak 4
1. Women's Health Center, American Hospital, Istanbul, Turkey
2. Marmara University, School Of Medicine, Department Of Pathology, Istanbul, Turkey
3. Marmara University, School Of Medicine, Department Of Histology, Istanbul, Turkey
4. Marmara University, School Of Medicine, Department Of Obstetrics And Gynecology, Istanbul, Turkey
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ABSTRACT

Conclusion:

These results suggest that trophoblast apoptosis is increased in the preeclamptic placentas and that this form of apoptosis is different from that occurring with placental aging as a consequence of cell turnover.

Results:

Both groups were comparable in terms of age and parity. However, mean gestational week was significantly lower (33.2±3.2 vs. 39.1±0.5 p<0.0001, respectively), and apoptotic rate in the trophoblasts were significantly higher (40.7±17.9 vs. 25.2±10.6, p<0.05, respectively) in the preeclamptic group compared to controls.

Patients and methods:

28 preeclamptic and 10 healthy control placentas were used for the study. Apoptosis in the trophoblasts were analyzed using TUNEL method and electron microscopy techniques.

Objective:

We aimed in this study to determine if trophoblastic apoptosis is increased in placentas from preeclamptic women compared to healthy term control placentas.