Dear Editor,

We would like to share ideas on the publication “The association between increased maternal Parkinson disease protein 7 (PARK7) (DJ-1) levels and the occurrence of preterm premature rupture of membranes (PPROM) - A randomized prospective study⁽¹⁾.” Turhan and Tatar⁽¹⁾ concluded that “PARK7 is overexpressed in PPROM patients. Due to its anti-inflammatory and antioxidant properties, PARK7 may be a novel marker in better understanding the pathophysiology and prediction of the prognosis PPROM. Further large-scale studies are needed⁽¹⁾.” We agree that PARK7 might be useful for management of PPROM. However, as Turhan and Tatar⁽¹⁾ noted, further studies are required. Other obstetric complication such as pre-eclampsia also affect level of DJ-1⁽²⁾. Also, quality control in analysis of the DJ-1 is necessary. In clinical chemistry, different centrifugation condition can significantly affect measurement of DJ-19⁽³⁾. These factors are important considerations in using maternal DJ-1 as biomarker.