ABSTRACT

The ai m of the study is to determine VEGF, EGFR and TGF- α with the immunohistochemical staining in placenta biopsies of patients with preeclampsia.

Prospective case control study.

Biopsies from the placenta were obtained from ten patients with preeclapmsia and ten patients of control group during the cesarean section. Placenta biopsies were examined for VEGF, EGF-R and TGF- α distribution with avidin-biotinperoxidase immunohistochemistry. The staining intensities were graded semi-quantitatively by the two histologists who were blinded to the groups and the H-score was calculated by light microscopic examination.

The VEGF, EGFR and TGF- α expression was significantly higher in placenta biopsies of preeclamptic patient compared to controls (271.2±22.65 versus 201.9±12.33, p=0.000; 186.3±4.98 versus 150.3±5.7, p=0.000; 185.1±7.48 versus 169.2±6.19, p=0.000; respectively).

Immunos taining of VEGF, EGF-R and TGF- α is signif icantly higher i n plac enta biopsi es in patie nts with preeclampsia.