E-ISSN: 2149-9330
Comparison of the efficacy and adverse effects of Trospium chloride and Tolterodine in the treatment of overactive bladder symptoms
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Clinical Investigation
VOLUME: 5 ISSUE: 2
P: 118-122
June 2008

Comparison of the efficacy and adverse effects of Trospium chloride and Tolterodine in the treatment of overactive bladder symptoms

Turk J Obstet Gynecol 2008;5(2):118-122
Melih Atahan Güven 1
Ayhan Coşkun 1
Arif Güngören 2
Önder Ercan 1
Savaş Karakuş 1
Özgür Özdemir 1
1. Kahramanmaras Sutcu Imam University, Department Of Obstetrics And Gynecology, Kahramanmaras
2. Mustafa Kemal University, Department Of Obstetrics And Gynecology, Hatay
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ABSTRACT

OBJECTIVE:

To compare the efficacy and adverse effects of two antimuscarinic agents ( trospium chloride (TCl), tolterodine L-tartrate) in patients having overactive bladder symptoms.

MATERIAL-METHODS:

During 2005, patients admitted with urge incontinence to Faculty of Medicine, Gynaecology Clinic and answered overactive bladder evaluation questionnaire form, and given Tolterodine-L- Tartrate (Detrusitol ®) 2 mg, 2x1 (n: 38), Trospium chloride (Spazmex ®) 30 mg tb 2x1 (n: 41), were retrospectively evaluated. Patients taken both drugs were determined by giving points regarding efficacy and adverse effects as questioned in the questionnaire form at the 1st and 3rd months following the initiation of treatment.

RESULTS:

Demografic data were similar in both groups (p>0.05). Points given after treatment were found significantly lower than the points given before treatment in both groups (p<0.001). The efficacy and adverse effects of both drugs were found statisticaly similar (p>0.05).

CONCLUSION:

In the highligths of retrospevtive data, we concluded that Trospium chloride and Tolterodine may be used alternatively to each other in treatment of overactive bladder.

Keywords:
Overactive bladder, Trospium chloride, Tolterodine