E-ISSN: 2149-9330
Comparison of mean platelet volume and serum bile acid levels in intrahepatic cholestasis of pregnancy
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Clinical Investigation
VOLUME: 10 ISSUE: 4
P: 236-241
December 2013

Comparison of mean platelet volume and serum bile acid levels in intrahepatic cholestasis of pregnancy

Turk J Obstet Gynecol 2013;10(4):236-241
DOI: 10.5505/tjod.2013.82653
Nilgün Güdücü 1
Başak Özge Kayan 1
Herman Işçi 1
Kılıç Aydınlı 2
Alin Başgül Yiğiter 1
İlkkan Dünder 1
1. Istanbul Bilim University Avrupa Florence Nightingale Hospital Department Of Obstetrics And Gynecology
2. Istanbul University, Cerrahpasa Medical School, Emeritus
No information available.
No information available
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ABSTRACT

Objective:

The aim of this study was to investigate the relationship between serum bile acid levels (SBA) and mean platelet volume (MPV), a proinflammatory marker and to detect the role of MPV as a marker of fetal well-being in patients with intrahepatic cholestasis of pregnancy (ICP).

Method:

We compared the biochemical parameters of pregnants with ICP and the control group retrospectively.

Results:

Pregnants with ICP had statistically significantly higher alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fasting SBA levels and the gestational week at delivery was higher in the control group (p < 0.05). There was no statistically significant relationship between MPV and hemoglobin, hematocrite, white blood cell count and thrombocyte levels of the groups ( p > 0.05). Mean gestational week at delivery was statistically significantly lower in pregnants with ICP when compared to the control group (37.95 ± 0.92 weeks and 37.25 ± 1.25 weeks, p < 0.05 respectively).

Conclusions:

There was no relationship between MPV and biochemical parameters used to define ICP. But the rate of preterm delivery increased as SBA levels increased.