Changes in serum paraoxonase activity, calcium and lipid profiles in pre-eclampsia, a priliminary study

Turk J Obstet Gynecol 2011;8(3):169-174

DOI: 10.5505/tjod.2011.24540

1. Dicle University, Department Of Obstetrics And Gynecology, Diyarbakir, Turkey

2. Dicle University, Department Of Biochemistry, Diyarbakir, Turkey

3. Istanbul Bilim University, Gayrettepe Florence Nightingale Hospital, Department Of Obstetrics And Gynecology, Istanbul, Turkey

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ABSTRACT

Objective:

To investigate serum paraoxonase (PON1) activity, serum calcium, and lipid profiles in pre-eclampsia.

Material & Method:

Serum PON1 activity, calcium, and lipid profiles were measured in a cohort of 45 women with normal pregnancies (11 patients) and pre-eclampsia (34 patients).

Results:

Triglyceride, total cholesterol, and LDL cholesterol concentrations were significantly increased in women with pre-eclampsia, compared with women with normal

Pregnancies:

Serum HDL cholesterol, PON1, and calcium levels in pre-eclamptic patients were significantly lower than those in healthy pregnant women.

Conclusion:

The significant decrease of PON1 activity in pre-eclampsia is related to lipid profiles and calcium.