E-ISSN: 2149-9330
Activated protein C resistance, endogenous anticoagulants and coagulation parameters in recurrent pregnancy loss
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Clinical Investigation
VOLUME: 8 ISSUE: 4
P: 244-248
December 2011

Activated protein C resistance, endogenous anticoagulants and coagulation parameters in recurrent pregnancy loss

Turk J Obstet Gynecol 2011;8(4):244-248
DOI: 10.5505/tjod.2011.99705
Gökalp Öner 1
İptisam İpek Muderris 1
Çetin Saatci 2
1. Department Of Obstetric And Gynecology, Erciyes University, Kayseri, Turkey
2. Department Of Genetic, Erciyes University, Kayseri, Turkey
No information available.
No information available
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ABSTRACT

Objective:

Recurrent miscarriage is usually defined as three or more consecutive miscarriages before 20 weeks and it occurs in 0.5%–1% of total pregnancies. Therefore, activated protein C resistance (APCR), protein C and S deficiency, antithrombin deficiency is important pathologies for RPL. In this study, our aim was to assess the role of thrombophilia parameters in RPL.

Material and Methods:

35 patients with RPL and 53 healthy control withot RPL were included in this study. Exclusion criterias of this study were uterin anomalies, chronic systemic disease, antiphospholipid and anticardiolipin antibodies entity that caused RPL.

Results:

There was no difference between two groups for ages. The mean pregnacy loss of 35 patients with RPL was 3.57 ± 1.54 (3-11 items). When patients were compared for the APC resistance, there was a significant difference between the groups. Although the values of protein C, protein S and antithrombin III were low, there was no statistically significant difference between groups.

Conclusion:

Throbophilia including APC resistance, protein C and S deficiency, antithrombin deficiency is associated with RPL. Thrombophilia is consequential for the prognosis of pregnancy and is considered for the following of pregnancy in patients with pregnancy.