Abstract
Objective:
The aim of this study was to investigate the relationship between serum bile acid levels (SBA) and mean platelet volume (MPV), a proinflammatory marker and to detect the role of MPV as a marker of fetal well-being in patients with intrahepatic cholestasis of pregnancy (ICP).
Method:
We compared the biochemical parameters of pregnants with ICP and the control group retrospectively.
Results:
Pregnants with ICP had statistically significantly higher alanine aminotransferase (ALT), aspartate aminotransferase (AST) and fasting SBA levels and the gestational week at delivery was higher in the control group (p < 0.05). There was no statistically significant relationship between MPV and hemoglobin, hematocrite, white blood cell count and thrombocyte levels of the groups ( p > 0.05). Mean gestational week at delivery was statistically significantly lower in pregnants with ICP when compared to the control group (37.95 ± 0.92 weeks and 37.25 ± 1.25 weeks, p < 0.05 respectively).
Conclusions:
There was no relationship between MPV and biochemical parameters used to define ICP. But the rate of preterm delivery increased as SBA levels increased.
Keywords: serum bile acid levels, mean platelet volume, pregnancy
