OBJECTIVE: To discuss the increase in chromosomal anomalies after intracytoplasmic sperm injection(ICSI), a form of assisted reproductive technology, in the form of a case report. Design: Incidense of chromosomal anomalies in ART; review of the literature. Setting: Gazi University Faculty of Medicine Obstetrics and Gynecology Department, Besevler, Ankara Patient: A secondary infertile patient underwent ICSI procedure resulting in a quadruplete pregnancy. Spontaneous reduction of two gestational sacs occured at 12th week. Amniocenthesis result of one fetus was reported as Turner Syndrome. Intrauterin growth retardation and oligohydramniose are diagnosed in the other fetus at 30th week. Cesarian section is applied at 36th week and a 2200 gram healthy female baby is delivered with the apgar scores of 10/10 Intervention: Amnicenthesis is applied to the ICSI pregnant patient at 17th week. Main outcome measures: Amniocenthesis report was Turner Syndrome (45 X0) RESULTS: Incidence of chromosomal anomalies increase in ICSI pregnant patients CONCLUSIONS: Regarding advanced age of patients, chromosomal instability due to in vitro manipulations of sperm and oocytes, there is an increase in the incidence of chromosomal anomalies in transferred embryos and intrauterin fetuses.
Keywords: ICSI, oligohydroamniose, turner syndrome