Clinical Investigation

The value of creatine kinase, estradiol and progesterone levels in early diagnosis of ectopic pregnancies: a prospective controlled study

  • Feride Mimaroğlu
  • Cem Dane
  • Banu Dane
  • Ahmet Çetin
  • Murat Erginbaş
  • Murat Kıray

Turk J Obstet Gynecol 2010;7(2):133-138


To evaluate the role of serum creatine kinase, progesterone and estradiol as a biochemical marker in the early diagnosis of tubal pregnancy.


A prospective controlled study was carried out on 44 women with first trimester pregnancy. First group (n=22) with tubal pregnancy formed the study group and second group (n=22) with normal intrauterine pregnancy was taken as controls. Serum beta hCG, creatine kinase, progesterone and estradiol levels in the two groups were compared. Surgical treatment had choosen as a treatment modality of ectopic pregnancy.


The optimal cutoff value of creatine kinase to be used for the prediction of ectopic pregnancy was 45 IU/l, which resulted in a sensitivity of 86%, specificity of 31%, positive predictive value 55 % and negative predictive value 70 %. The same values for estradiol and progesterone were detected >225 pg/ml, 100 %, 68 %, 75%, 100 % and >13 ng/mL, 95 %, 81 %, % 84, % 97 in discriminating ectopic pregnancies. According to AUC levels there was a significant difference between estradiol-creatine kinase levels, progesterone-estradiol levels and progesterone–creatin kinase levels (p values 0.024, 0.0082, and 0.0001, respectively).


Serum creatine kinase values appear to be a useful marker in the diagnosis of ectopic pregnancy.

Keywords: Biochemical marker, ectopic pregnancy, creatinine kinase, progesterone, ROC curve.