Clinical Investigation

The effects of prognostic factors on pregnancy success among women 39 years or older having intracytoplasmic sperm injection


  • Seda Sultan Doğan
  • Müge Kovalı
  • Ömer Erbil Doğan
  • Bülent Gülekli

Received Date: 05.08.2013 Accepted Date: 27.01.2014 Turk J Obstet Gynecol 2014;11(2):78-83


The objective of this study is to investigate the effect of age on the prognostic factors and fertilization potential of infertile women who are 39 years or older.

Material and methods:

107 patients with advanced maternal age (≥39 years) were included in this retrospective study. The endometrial thickness on the day of human chorionic gonadotropin (hCG), total dose of gonadotropin used, duration of stimulation, levels of day-3 basal follicule stimulating hormone (FSH) and basal estradiol (E2), number of retrieved oocytes and fertilized oocytes, and number of embryos transferred were recorded. These parameters were used to evaluate their effects on the success of pregnancy. Patients were categorized into three age groups: 39 years old (n=47), 40-41 years old (n=37), and ≥ 42 years old (n=23) and age groups were compared.


The rate of live birth was %23.2 in 39 years and %14.7 in 40-41 years. No live birth in 42 years or older patients was recorded. The results revealed that that the age, number of retrieved oocytes and fertilized oocytes predict the success rate of pregnancy.


Pregnancy rate dramatically decreased after the age of 39; the success of pregnancy after the intracytoplasmic sperm injection decreases 9 times, three years later starting age of 39. The negative effect of advanced maternal age on pregnancy and live birth rates was observed in our clinical study, as well.

Keywords: Advanced female age, pregnancy rate, assisted reproductive treatment