Letter to the Editor

Maternal PARK7 (DJ-1) levels and the preterm premature rupture of membranes: Correspondence


  • Rujittika Mungmunpuntipantip
  • Viroj Wiwanitkit

Received Date: 28.12.2021 Accepted Date: 06.01.2022 Turk J Obstet Gynecol 2022;19(1):87-87 PMID: 35343223

Keywords: PARK7 (DJ-1), preterm premature rupture of membrane, maternal

Dear Editor,

We would like to share ideas on the publication “The association between increased maternal Parkinson disease protein 7 (PARK7) (DJ-1) levels and the occurrence of preterm premature rupture of membranes (PPROM) - A randomized prospective study(1).” Turhan and Tatar(1) concluded that “PARK7 is overexpressed in PPROM patients. Due to its anti-inflammatory and antioxidant properties, PARK7 may be a novel marker in better understanding the pathophysiology and prediction of the prognosis PPROM. Further large-scale studies are needed(1).” We agree that PARK7 might be useful for management of PPROM. However, as Turhan and Tatar(1) noted, further studies are required. Other obstetric complication such as pre-eclampsia also affect level of DJ-1(2). Also, quality control in analysis of the DJ-1 is necessary. In clinical chemistry, different centrifugation condition can significantly affect measurement of DJ-19(3). These factors are important considerations in using maternal DJ-1 as biomarker.


Peer-review: Internally peer-reviewed.

Financial Disclosure: The authors declared that this study received no financial support.

  1. Turhan U, Tatar B. The association between increased maternal PARK7 (DJ-1) levels and the occurrence of preterm premature rupture of membranes - A randomized prospective study. Turk J Obstet Gynecol 2021;18:279-84.
  2. Yang T, Yan J, Han Q, Zhang Q, Liao Q. Expression and significance of Parkinson disease protein 7 in placental, serum and umbilical cord blood in preeclampsia. Ginekol Pol 2020;91:764-8.
  3. Salvesen L, Tanassi JT, Bech S, Pålhagen S, Svenningsson P, Heegaard NH, et al. The influence of preanalytical conditions on the DJ-1 concentration in human cerebrospinal fluid. Biomark Med 2014;8:387-94.