Introduction: Extra pelvic tumors metastasizing to the gynecological organs target usually ovaries. Uterine metastasis is quite rare. The most frequent source of metastasis toward to the uterus is breast and stomach. This paper describes a case of gastric signet-ring cell cancer of the stomach metastasizing to endometrium, which was diagnosed by endometrial sampling. Case: During the evaluation of a 48 years old woman who suffered from abdominal distention and weight loss, sonography revealed a 9x8 cm, solid mass arising from the left adnexial region. Among the tumor markers only CA 125 revealed elevated. Despite the normal result of cytological examination of ascite, endometrial biopsy revealed signet-ring cell tumor. She refused the chemotherapy and died five months after the initial diagnosis. Discussion: Myometrium is commonly invaded in uterine metastasis. Isolated endometrial metastasis is very seldom. Different pathways have been proposed for uterine metastasis. Dissemination to the uterus via reverse lymphatic drainage from tumors metastasizing to the pelvis, especially to the ovaries, or hematogenous spread is widely accepted ways for uterine involvement. These women frequently suffer from irregular bleeding and the diagnosis is made by endometrial sampling in most. Endometrial biopsy should not be omitted in cases with menstrual irregularity for this reason.
Keywords: Endometrial cancer, gastric cancer, signet-ring cell tumor, metastasis, Krukenberg tumor