Clinical Investigation

Comparision of serum High Density Lipoprotein(HDL) and Sphingosine 1 Phosphate(S1P) levels between the hypertensive and normotensive pregnancies.

10.5505/tjod.2011.63497

  • Erkan Dilmen
  • Ilker Günyeli
  • Baha Oral
  • Evrim Erdemoglu
  • Mehmet Güney
  • Gökhan Bayhan
  • Tamer Mungan

Turk J Obstet Gynecol 2011;8(3):164-168

Comparison of serum High Density Lipoprotein (HDL) and Sphingosine 1 Phosphate (S1P) levels between the hypertensive and normotensive pregnancies. Objective: To compare serum High Density Lipoprotein (HDL) and associated Sphingosine-1-Phosphate (S1P) levels between hypertensive and normotensive pregnant women, and to study likely effect of these parameters on the development of hypertension. Design: A comparative cohort study. Setting: This prospective study was conducted between December 2008 and March 2009 at Department of Obstetrics and Gynecology, Suleyman Demirel University, Isparta. Interventions: Plasma S1P and HDL levels were analyzed. Material and Method: S1P levels and HDL levels were analyzed by ELISA. Results: Forty normotensive and 40 hypertensive pregnant women was included to the study. Demographical and obstetrical characteristics of patients were similar. SP1 and HDL levels were 0,6±0.32 nM and 61.6±15.3 mg/dl in hypertensive pregnant women. SP1 and HDL levels were 2,1±10.8 nM and 60.2±14.4 mg/dl in normotensive pregnant women. There was no statistically significant difference between groups.  Conclusion: We concluded that further studies are needed to evaluate the effects of HDL and associated S1P upon the vascular tonus in hypertensive diseases of pregnancies.

Keywords: preeclampsia, HDL, S1P