Case Report

A prenatally diagnosed pentalogy of cantrell case with encephalocele: A rare variant

  • Melih Atahan Güven
  • Gülay Ceylaner
  • Serdar Ceylaner
  • Ayhan Coşkun
  • Hakan Bayazıt

Turk J Obstet Gynecol 2009;6(2):123-127


The aim of this study is to present a prenatally diagnosed and postnatally confirmed Pentalogy of Cantrell case also with neural tube defect.


Characteristic features of Cantrell Pentalogy are omphalocele due to the defect of anterior diaphragm and lower sternum, absence of pericardium and cardiac anomaly. We are presenting here a case with encephalocele and omphalocele containing the heart with atrioventricular septal defect detected during prenatal ultrasonography. There is no consanguinity and history of drug usage or toxin exposure during pregnancy. As these malformations cause a very low chance of survival, pregnancy was terminated after an informed consent. Postmortem genetic evaluation of the fetus confirmed the prenatal findings.


It is easy to diagnose omphalocele during pregnancy but if it associates with heart anomalies, Cantrell Pentalogy must be remembered. Encephalocele and other types of neural tube defects very rarely associate with this disorder and there were fewer than 20 cases reported in the literature.

Keywords: Pentalogy of Cantrell, Encephalocele, Pregnancy, Prenatal Diagnosis, Ultrasonography, Postmortem Genetic Evaluation