Clinical Investigation

A Comparison Between Parenteral Paracetamol and Diclofenac For Acut Postoperetive Pain Treatment in Patients After Caeserean Section

  • Süleyman Akarsu
  • Şaziye Şahin
  • Cengiz Kara
  • Nermin Akdemir
  • Semih Değerli

Turk J Obstet Gynecol 2010;7(4):262-266

The aim of this study was to assess the analgesic efficacy and adverse effects of intravenous paracetamol in comparison with intramuscular diclofenac in patients with postoperative pain after Cesarien section (C/S Abdominale ). Eighty patients of ASA class I-II, 20-39 years of age, undergoing C/S under spinal anesthesia were assigned in a randomized manner into two groups. In Group 1 (n=40), 1 gr paracetamol intravenously, in Group 2 (n=40) 75 mg diclofenac intramuscularly was given at the time to first analgesic requirement after the operation.

Postoperative pain scores were evaluated before medicine and at 30 min., 1, 2, 4, and 6 hours after the administration of the analgesic. 1 mg/kg meperidine was given in patients whom VAS ≥5 after the analgesic. First analgesic time and adverse effects such as nausea, vomiting, pruritis, injection site pain, allergic reaction, hypotension and hypertension were recorded. The demographic data, and adverse effects were similar in all groups. No significant differences were found between paracetamol and diklofenac for measures of analgesic activity.

Keywords: intravenous paracetamol, diclofenac sodium, postoperative analgesia, cesarean section, nonopioid analgesic