Objective(s):
Preterm Premature rupture of membranes (PPROM) is defined as rupture of membranes that happens before onset of labor and 37 weeks. Subclinical intrauterine infection is major etiological factor in the pathogenesis of PPROM. This study was performed to evaluate the levels of maternal serum uPAR ST2 and IL-33 in PPROM to determine the possible chorioamnionitis without any clinical signs.
Study Design:
A total of 70 pregnant women, of which 45 with PPROM between 24 and 34 weeks gestation and 25 normal pregnant women without PPROM were included in the study. Study group was seperated into two subgroups as PPROM and PPROM- HC (histological chorioamnionitis).
Results:
The mean serum IL-33, ST2 and uPAR values in the PPROM-HC group were significantly higher than PPROM and control group.
Conclucion:
These results suggest that uPAR, ST2, IL-33 and IL-6 can be used as reliable biomarkers to determine infection without any clinical signs.
Keywords: Corioamnionitis, PPROM, IL-33, uPAR