Placental site trophoblastic tumor (PSTT) is a rare variant of gestational trophoblastic disease (GTD) that originates from the implantation site intermediate trophoblast. In this case report, a case of 28-year-old female with PSTT is presented. She admitted to our clinic with irregular vaginal bleeding and a positive urine pregnancy test. Her antecedent pregnancy was a full-term normal pregnancy and interval from the antecedent pregnancy was 14 months. The diagnosis of PSTT was established by dilatation and curettage and subsequently simple hysterectomy was performed with preservation of grossly normal ovaries. Pathologic examination of hysterectomy specimen revealed tumor infiltration limited to the uterine serosa. However, administration of 6 cycles of adjuvant multidrug chemotherapy with VAC (Vincristin, Actinomycin-D and Cyclofosfamid) was decided because of the high mitotic rate and the presence of extensive coagulative necrosis.
Keywords: Placental site trophoblastic tumor, hysterectomy and chemotherapy