OBJECTIVE: To determine the controlled ovarian hyperstimulation (COH) response and intracytoplasmic sperm injection (ICSI) performance of women with single ovary. Design: Retrospective clinical trial. Setting: Hacettepe University Faculty of Medicine, Department of Obstetrics and Gynecology, IVF Clinic Patients: 12 patients (22 cycles) with single ovary and 45 patients (with both ovaries, 66 cycles) with tubal factor infertility. Interventions: Controlled ovarian hyperstimulation (COH), intracytoplasmic sperm injection (ICSI) Main outcome measures: Rate of cycle cancellation, number of oocyte yield, number of metaphase 2 oocyte yield, number of 2PN yield and clinical pregnancy rate RESULTS: The cycle cancellation rate of single ovary and control groups were 31.8% and 18.2%, respectively (p>0.05). The single ovary group produced less number of oocytes, metaphase 2 oocytes and 2PN in controlled ovarian hyperstimulation. However, the number of transferred embryos and the rate of clinical pregnancy in both groups were comparable. CONCLUSIONS: The single ovary is associated with decrease COH ovarian response. Since sufficient number of embryos for transfer could be available, the detrimental affect of single ovary on COH response does not alter the clinical pregnancy rates.

Keywords: ICSI, clinical pregnancy, ovarian reserve, single ov