OBJECTIVE: The aim of the study was to compare bone mineral density measurements between patients with polycystic ovary syndrome (PCOS) and age and body mass index matched healthy controls, and to examine whether plasma adrenomedullin concentration was associated with bone mineral density. Design: Prospective study. Setting: Department of Obstetrics and Gynecology, Kirikkale University School of Medicine. Patients: Twenty women with PCOS and 13 healthy control subjects were enrolled in the study. Interventions: Plasma adrenomedullin, serum androstenedione, free testosterone, testosterone, DHEAS, SHBG, FSH, LH, estradiol, fasting insulin and fasting glucose were measured in each subject. Bone mineral density (lumbar spine 2-4 (L2-4), femoral neck, ward's triangle, great trochanter) measurements were measured using dual energy X-ray absorptiometry. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75 g of glucose tolerance test for 2 hours.Main Outcome Measures: Bone mineral density and correlation between bone mineral density and plasma adrenomedullin. RESULT: Bone mineral density measurements did not differ between the groups. There were no correlations between plasma adrenomedullin and bone mineral density measurements. CONCLUSIONS: Further studies are needed to evaluate the relation between bone mineral density and plasma adrenomedullin.
Keywords: Polycystic ovary syndrome, adrenomedullin, bone mineral density.