Clinical Investigation

Activated protein C resistance, endogenous anticoagulants and coagulation parameters in recurrent pregnancy loss


  • Gökalp Öner
  • İptisam İpek Muderris
  • Çetin Saatci

Turk J Obstet Gynecol 2011;8(4):244-248


Recurrent miscarriage is usually defined as three or more consecutive miscarriages before 20 weeks and it occurs in 0.5%–1% of total pregnancies. Therefore, activated protein C resistance (APCR), protein C and S deficiency, antithrombin deficiency is important pathologies for RPL. In this study, our aim was to assess the role of thrombophilia parameters in RPL.

Material and Methods:

35 patients with RPL and 53 healthy control withot RPL were included in this study. Exclusion criterias of this study were uterin anomalies, chronic systemic disease, antiphospholipid and anticardiolipin antibodies entity that caused RPL.


There was no difference between two groups for ages. The mean pregnacy loss of 35 patients with RPL was 3.57 ± 1.54 (3-11 items). When patients were compared for the APC resistance, there was a significant difference between the groups. Although the values of protein C, protein S and antithrombin III were low, there was no statistically significant difference between groups.


Throbophilia including APC resistance, protein C and S deficiency, antithrombin deficiency is associated with RPL. Thrombophilia is consequential for the prognosis of pregnancy and is considered for the following of pregnancy in patients with pregnancy.

Keywords: thrombophilia, recurrent pregnancy loss